Introduction, Ian H. Gotlib & Constance L. Hammen I. Descriptive Aspects of Depression 1. Epidemiology of Depression, Ronald C. Kessler, Peter de Jonge, Victoria Shahly, Hanna M. van Loo, Philip S. E. Wang, Marsha A. Wilcox 2. Assessment of Depression, Arthur M. Nezu, Christine Maguth Nezu, Minsun Lee, & Jessica B. Stern 3. Methodological Issues in the Study of Depression, Rick G. Ingram, Greg J. Siegle, & Dana Steidtmann 4. Course of Depression: Persistence and Recurrence, Daniel N. Klein & Anna E. S. Allmann 5. Comorbidity of Unipolar Depressive and Anxiety Disorders, Susan Mineka & Suzanne Vrshek-Schallhorn 6. Emotional Functioning in Depression, Jonathan Rottenberg & Lauren M. Bylsma 7. Depression and Medical Illness, Kenneth E. Freedland & Robert M. Carney 8. Features and Course of Bipolar Disorder, Eric Youngstrom & Guillermo Perez Algorta II. Vulnerability, Risk, and Models of Depression 9. The Genetics of Mood Disorders, Jennifer Y. F. Lau, Kathryn J. Lester, Karen Hodgson, & Thalia C. Eley 10. Neurobiological Aspects of Depression, Michael E. Thase, Chang-Gyu Hahn, & Olivier Berton 11. Neuroimaging Approaches to the Study of Major Depressive Disorder: From Regions to Circuits, A. Pizzagalli & Michael T. Treadway 12. Early Adverse Experiences and Depression, Sherryl H. Goodman & Cara M. Lusby 13. Children of Parents with Depression, Ian H. Gotlib & Natalie L. Colich 14. Cognitive Aspects of Depression, Jutta Joormann & Kimberly Arditte 15. Depression and Interpersonal Processes, Constance L. Hammen & Josephine Shih 16. The Social Environment and Depression: The Roles of Life Stress, Scott M. Monroe, George M. Slavich, & Katholiki Georgiades 17. Risk Factors for Bipolar Disorder, Sheri L. Johnson, Amy K. Cuellar, & Andrew D. Peckham III. Depression in Specific Populations 18. Understanding Depression across Cultural Contexts, Yulia E. Chentsova-Dutton & Andrew G. Ryder, Jeanne Tsai 19. Gender Differences in Depression, Lori M. Hilt & Susan Nolen-Hoeksema 20. Depression in Children, Brandon E. Gibb 21. Depression in Adolescents, Karen D. Rudolph & Megan Flynn 22. Depression in Couples and Families, Joanne Davila, Catherine B. Stroud, & Lisa R. Starr 23. Depression in Later Life: Epidemiology, Assessment, Impact, and Treatment, Dan G. Blazer & Celia F. Hybels 24. Depression and Suicide, Matthew K. Nock, Alexander J. Millner, Charlene A. Deming, & Catherine R. Glenn IV. Prevention and Treatment of Depression 25. Major Depression Can Be Prevented: Implications for Research and Practice, Ricardo F. Muñoz, Stephen M. Schueller, Alinne Z. Barrera, Huynh-Nhu Le, & Leandro D. Torres 26. Pharmacotherapy and Other Somatic Treatments for Depression, Michael J. Gitlin 27. Cognitive and Behavioral Treatment of Depression, Steven D. Hollon & Sona Dimidjian 28. Pharmacotherapy and Psychosocial Treatments for Bipolar Disorder, David J. Miklowitz 29. Couple, Parenting, and Interpersonal Therapies for Depression in Adults: Toward Common Clinical Guidelines within a Stress-Generation Framework, Steven R. H. Beach, Mark A. Whisman, & Guy Bodenmann 30. Biological and Psychosocial Interventions for Depression in Children and Adolescents, Nadine J. Kaslow, Marissa N. Petersen-Coleman, & Ashley Maehr Alexander Closing Comments and Future Directions, Constance L. Hammen & Ian H. Gotlib