Handbook of Experimental Neurology Methods and Techniques in Animal Research

Handbook of Experimental NeurologyMethods and Techniques in Animal Research

An essential 2006 reference volume covering major methodologies and disease models in current neuroscience research.

Turgut Tatlisumak (Edited by), Marc Fisher (Edited by)

9780521184205, Cambridge University Press

Paperback / softback, published 23 December 2010

594 pages
24.4 x 17 x 3.1 cm, 0.93 kg

Basic relevant information on methodologies used in neurological disease models can be extremely hard to find. Originally published in 2006, this important reference work contains 30 chapters from over 60 internationally recognized scientists and covers every major methodology and disease model used in neuroscience research. Divided into two major sections, the first deals with general methodologies in neuroscience research covering topics from animal welfare and ethical issues to surgical procedures, post-operative care and behavioral testing. Section two covers every major disease model including traumatic brain injury, ischemia and stroke, to Parkinson's, motor neurone disease, epilepsy and sleep disorders. Delivering critical methodological information and describing small animal models for almost all major neurological diseases, this book forms an essential reference for anyone working in neuroscience, from beginning students to experienced researchers and medical professionals.

PrefacePart I. Principles and General Methods: 1. Introduction: Animal modelling - a precious tool for developing remedies to neurological diseases Turgut Tatlisumak and Marc Fisher2. Ethical issues, welfare laws, and regulations David Whittaker3. Housing, feeding, and maintenance of rodents Robert W. Kemp4. Identification of individual animals Turgut Tatlisumak and Daniel Strbian5. Analgesia, anesthesia, and postoperative care in laboratory animals Naoya Masutomi and Makoto Shibutani6. Euthanasia in small animals Turgut Tatlisumak7. Various surgical procedures in rodents René Remie8. Genetically engineered animals Carolina M. Maier, Lilly Hsieh and Pak H. Chan9. Imaging in experimental neurology Marc Fisher, Eng H. Lo and Michael Lev10. Safety in animal facilities Tarja Kohila11. Behavioural testing in small animal models: ischemic stroke Larry B. Goldstein12. Methods for analysing brain tissue Päivi Liesi13. Targeting molecular constructs of cellular function and injury through in vitro and in vivo experimental models Zhao Zhong Chong, Faqi Li and Kenneth Maiese14. Neuroimmunology and immune-related neuropathologies Bao-Guo Xiao and Hans Link15. Animal models of sex differences in non-reproductive brain functions George T. Taylor, Juergen Weiss and Frank Zimmermann16. The ependymal route for central nervous system gene therapy Erica Butti, Gianvito Martino and Roberto Furlan17. Neural transplantation Stephen B Dunnett, Eduardo M. Torres, Monte A. Gates, and Rosemary A. Fricker-GatesPart II. Experimental Models of Major Neurological Diseases: 18. Focal brain ischemia models in rodents Fuhai Li and Turgut Tatlisumak19. Rodent models of global brain ischemia Julia Kofler and Richard J. Traystman20. Rodent models of hemorrhagic stroke Fatima A. Sehba and Joshua B. Bederson21. In-vivo models of traumatic brain injury Ronen R Leker and Shlomi Constantini22. Experimental models for the study of CNS tumors Taichang Jang and Lawrence Recht23. Experimental models for demyelinating diseases Jason M Link, Richard E. Jones, Halina Offner and Arthur A Vandenbark24. Animal models of Parkinson's disease Anumantha G. Kathasamy and Siddharth Kaul25. Animal models of epilepsy Ricardo M. Arida, Alexandre V. Silva, Margareth R. Priel, and Esper A. Cavalheiro26. Experimental models of hydrocephalus Osaama H. Khan and Marc R. Del Bigio27. Rodent models of experimental bacterial infections in the CNS Tammy Kielian28. Experimental models of motor neuron disease Ruth Danzeisen, Birgit Schwalenstöcker and Albert C Ludolph29. Animal models for sleep disorders Seiji Nishino and Nobuhiro Fujiki30. Experimental models of muscle diseases Anu Suomalainen, Katja E. Peltola, Anders Paetau and Carina Wallgren-Pettersson.

Subject Areas: Neurosciences [PSAN], Neurology & clinical neurophysiology [MJN]