Margaret W. Mann is Associate Professor and Director of Aesthetic Dermatology, University Hospitals, Case Western School of Medicine, Cleveland, OH, USA. She is the Co-Founder of Innova Dermatology, Hendersonville, TN, USA. Daniel L. Popkin is Assistant Chief of Dermatology, Louis Stokes VA Medical Center and Assistant Professor of Dermatology, University Hospitals, Case Western School of Medicine, Cleveland, OH, USA. He is the Co-Founder of Innova Dermatology, Hendersonville, TN, USA.
Preface xv Acknowledgments xvii Part 1 General Dermatology 1 Common Work-Ups, Signs, and Management 3 Dermatologic Differential Algorithm 3 Direct Immunofluorescence (Dif) 3 False positive/negative DIFs 3 Workup Quick Reference Orders 4 Acne 6 Alopecia Workup 7 Telogen effluvium 10 Androgenic alopecia 10 Alopecia areata 11 Other alopecia treatments 12 Aphthosis Workup and Treatment 13 Dermatologic Signs 15 Folliculitis 21 Melasma 22 Immunology and Immunologic Disease 24 Lupus Erythematosus 24 Autoantibody 26 Sensitivities and specificities 26 In connective tissue diseases 28 Anti-nuclear antibodies 29 ANCA (Anti-neutrophil cytoplasmic antibodies) 30 Treatment of ANCA-associated vasculitis 30 Vasculitis 31 Small vessel vasculitis 31 Medium vessel vasculitis 33 Large vessel vasculitis 34 Cryoglobulinemia 34 Bullous Disorders 36 Intracorneal/subcorneal 36 Intraepidermal 36 Suprabasilar 37 Subepidermal with little inflammation 37 Epidermolysis bullosa 39 Major bullous diseases - clinicopathologic findings 42 Complement 46 Angioedema and complement levels 46 Complement deficiencies 47 GVHD 47 HLA associations 48 Th profiles 50 Special Sites: Glands, Nail, Bone, Mucosa 51 Glands 51 Nail terminology 53 Disorders or drugs associated with nail, Bone, or ocular findings 57 Genital ulcers 67 Infection and Infestations 68 Fungal Disease / Mycoses 68 Laboratory tests 68 Superficial mycoses 68 Cutaneous mycoses 69 Subcutaneous mycoses 71 Systemic mycoses 73 Opportunistic mycoses 75 Viruses and diseases 78 Human papilloma virus 79 Other viral diseases 80 Infections/Bugs 83 Vector-borne diseases 83 Creatures in dermatology 88 Contact and Plant Dermatitis 93 Patch testing 93 Common contact allergens 95 Allergic vs. irritant contact dermatitis 104 Allergens - location specific 105 Features suggestive of specific irritant/toxin 106 Plants and Dermatoses 106 Tumors and Infiltrates 109 Cutaneous T Cell Lyphoma 109 Cutaneous B-cell lymphoma 113 Leukemia cutis 113 Monoclonal Gammopathies in Dermatology 114 Tumors and gene associations 115 For Melanoma, BCC, and SCC, see Skin Cancer 221 Systemic and Metabolic Diseases 117 Amyloidoses 117 Histiocytosis 119 Xanthomas 124 Hyperlipoproteinemias 125 Vitamin Deficiencies/Hypervitaminoses 127 Pediatric and Pregnancy Dermatology 131 Vascular tumors and malformation 131 Infantile Hemangioma (IH) Management 132 Neonatal vesiculopustular eruptions 137 Genodermatoses 142 Chromosome abnormalities 171 Disorders of cornification 171 Disorders of connective tissue 175 Ehlers-Danlos 177 Collagen types 178 Disorder of hair, Nail, ectoderm 179 Tumor syndromes 185 Disorders of vascularization 186 Disorders of metabolism 189 Porphyrias 191 Disorders of pigmentation 193 Immunodeficiency syndromes 196 Miscellaneous 198 Dermatoses of pregnancy 200 Dermoscopy and Dermatopathology 202 Dermoscopy 202 Dermatopathology 206 Histochemical staining 206 Immunohistochemical staining 207 Pathologic bodies 210 Cysts 214 Other derm path buzzwords, Patterns, DDx 215 Part 2 Surgical and Cosmetic Dermatology 219 Surgical Dermatology 221 Skin cancer 221 Surgical margin guidelines 221 Indication for Mohs micrographic surgery 222 Melanoma 223 Squamous cell carcinoma (SCC) 228 Prophylactic antibiotics and antivirals 230 Guideline for Prophylactic antibiotics 230 Algorithm for antibiotic prophylaxis 231 Guideline for prophylactic antivirals 231 Antiseptic scrubs 232 Anesthetics 234 Dose calculation 234 Standard formula for buffered Lidocaine 234 Tumescent anesthesia 234 Topical anesthetic (see drug section pg. 316) 235 Adverse reaction to local anesthetics 235 Local anesthetic 236 Nerve blocks 237 Surgical anatomy 237 Anatomy of the face 237 Danger zones in surgery 242 Dermatomal distribution of sensory nerves 244 Anatomy of the lower extremity venous system 245 Anatomy of the nail 246 Cutaneous reconstruction 247 Undermining depths in reconstruction 248 Reconstruction algorithm: STAIRS 248 Sutures 260 Absorbable 260 Nonabsorbable 261 Suture removal time 262 Electrosurgery 262 Wound healing 262 Wound dressing 263 Cosmetic Dermatology 264 Laser 264 Laser fundamentals 264 Laser treatment of tattoo pigment 266 Photoinduced eye injury 267 Laser wavelength depth of penetration and the electromagnetic spectrum 268 Absorption spectra of major skin chromophores 268 Photodynamic therapy 269 Photosensitizer properties and options 269 PDT Protocol 270 UV spectrum 271 UV spectrum and wavelengths 271 UVB protection vs SPF 272 UV protection measurements 272 UV associations/specificities 273 Glogau wrinkle scale 273 Fitzpatrick skin type 274 Chemical peels 274 Pre-peel consideration 274 Peeling agents 275 Botulinum toxin 277 Injectable for adipolysis 280 Fillers 281 Protocol for vascular occlusion from fillers 288 Venous disease treatment 288 Vein treatment algorithm 288 Sclerotherapy 289 Preparing dilution of sclerosants 290 CEAP classification for venous disease 292 Venous clinical severity score 292 Part 3 Drugs and Therapies 293 Medication Quick Reference 295 Topical steroids classified by strength 295 Nonsteroidals 297 Commonly used drugs in dermatology 297 Systemic Medications 302 Antimalarials 302 Immunosuppressive agents 303 Systemic retinoids 306 Biologics 307 General Reference 310 Metric measurements 310 Dose calculations 310 Topical medication dispensing and absorption 310 Corticosteroid Dosage Equivalence 311 Acne - Topical 311 Antibiotics/antimicrobial 311 Keratolytics 312 Retinoids 313 Others 313 Acne - Oral 314 Antibiotics 314 Retinoids 315 Others 315 Analgesics 315 Anesthetics - topical (see also topical anesthetic pg. 235) 316 Anesthetics - topical compounded 316 Antibiotics 316 Topical/antiseptic 316 Systemic 317 Preoperative prophylaxis see pg. 230 Postoperative skin infection 319 Sensitivity 321 Regimens 322 STDs 323 Antifungals 324 Topical 324 Oral 325 Antifungal regimens 327 Candidal infection 327 Pityrosporum folliculitis 327 Onychomycosis 327 Tinea versicolor (Malassezia) 328 Tinea capitis 328 Tinea corporis 328 Tinea pedis 329 Antiparasitics 330 Scabies 330 Lice 330 Antivirals 331 HSV 331 Herpes zoster/VZV 333 Genital warts 333 Verruca vulgaris 334 Molluscum 334 Antihistamines 334 Sedating 335 Nonsedating 335 H2-blockers 335 Antipruritic 336 Topical 336 Oral 336 Anxiolytics/Sedation 338 Benzodiazepines 338 Antihistamines 339 Bleaching Agents/Depigmenting Agents 340 Hair 341 Alopecia - androgenic 341 Alopecia - areata 341 Hypertrichosis 342 Hypotrichosis - eyelash 342 Hyperhidrosis 342 Psoriasis 343 Topical agents 343 Tar 343 Anthralin/dithranol 343 Systemic agents 343 (see also Systemic Medications pg. 306) Rosacea 344 Antibiotics/antimicrobial - topical 344 Keratolytics 344 Vasoconstrictor 344 Other 344 Antibiotics - systemic 344 Seborrheic Dermatitis 345 Skin Cancer - Topical and Oral Chemotherapy 345 Actinic keratoses (AK) 345 Basal cell carcinoma (BCC) 346 CTCL 346 Melanoma 347 Vasoactive/Antiplatelet Agents 347 Vitamins/Nutritional Supplements 348 Wound Care 348 Miscellaneous Meds 348 Cytochrome P-450 interactions 349 Pregnancy Categories of Commonly Used Dermatologic Agents 350 Common Dermatologic Drugs and Teratogenic Effects 351 Dermatologic Drugs Reportedly Associated with Contraceptive Failure 352 Drug Eruptions 352 Chemotherapeutic Agents and Skin Changes 355 Antidote to extravasation of chemotherapeutic agents 358 UV Light Treatment 359 UVA/UVB dosing 359 NBUVB dosing 359 PUVA 359 Toxic Epidermal Necrolysis (TEN) Protocol 361 Diagnosis of TEN 361 Triage algorithm for TEN patients 362 Treatment for all TEN patients 363 Appendix I American Burn Assocation Burn Center Referral Criteria 364 Appendix SCORTEN Score 365 Appendix III IVIg 365 Appendix IV Further Reading for TEN/SJS 366 Index 367 Color plate section can be found facing page 208
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